20180305_publikation_amf_migration_vdhi.pdf - These reciprocal effects are cantly overexpressed in the classical and mesenchymal glio- similar to those observed previously for the same cell lines blastoma subtypes, which carry a worse prognosis,12 and in response to hypoxia.3,4 1598 Kathagen-Buhmann et al. GPI/AMF function in glioblastoma A B GPI/AMF AMFR 100 100 High expression High ...

 
It calls for the disaggregation of migration data by sex and age, and the inclusion of information on regular and irregular flows, the economic impacts of migration and refugee movements, human trafficking, the needs of refugees, migrants and host communities and other issues.. Craigslist mcallen tx en espanol

Migration policy framework for Africa and plan of action (2018 – 2030) Preface. Due to a multiplicity of factors that include poor socio-economic . conditions, political instability, conflict and civil strife, migration has been on the rise on the African Continent, and for some communities migration has become a survival strategy. InStates on asylum and migration, in particular by supporting funds to pool best practice on asylum. This can be done in part by setting up networks and exchanging information on legal migration and the integration of third-country nationals. 1.10 The EESC welcomes the importance given to flexibility in both funds, as this entails acknowledging Mar 28, 2014 · We present data on bilateral flows between 196 countries from 1990 through 2010 that provide a comprehensive view of international migration flows. Our data suggest a stable intensity of global 5-year migration flows at ~0.6% of world population since 1995. In addition, the results aid the interpretation of trends and patterns of migration ... Define and frame the use of AMF in non EU countries The AMF proposal enables third countries associated to the fund to be direct beneficiaries of Member States’ national programmes for the purpose of managing migration, and includes measures regarding readmission procedures, return and reintegration, as well as resettlement schemes. Sustainable Development Goals (SDGs) include migration-related targets on labour standards, human trafficking, transfer costs of remittances, etc. Target 10.7 calls on countries to facilitate safe, orderly and regular migration and to implement well-managed migration policies. Keeping track of the implementation 5 Term Description ML Machine Learning MME Mobile Mobility Entity mMTC Mobile Machine Type Communications MO SMS Mobile-Originated Short MessageResearch revealed a major migration to the island of Great Britain 3,000 years ago, which offers fresh insights into the languages spoken at the time, the ancestry of present-day England and Wales, and even ancient habits of dairy consumption. Learn more about the British migration.AMF - Objectives Effective management of migration flows Common European Asylum System legal migration Integration and Return Solidarity and responsibility sharing Ensure efficient and uniform application of the Union acquis on asylum Set up and develop integration strategies at local/regional level (two way dynamic process, specific needs,IBM Program Directory for IBM Migration Utility V03.02.00 Program Number 5697-N44 FMID HMGU320 for Use with z/OS OS/390 Document Date: July 2009 GI10-3374-01Jan 14, 2020 · On the other hand, migration is the process of leaving one's own country or moving within a state to live elsewhere, regardless of the migrant's legal status, the nature of their journey ... A. Latest version of Migration Utility installed and functional B. Sample programs accessible by students C. Others to be listed in formal customer agreement Topics: 1. Introduction to Migration Utility 2. Executing Link & Go and Link-only programs 3. Finding and debugging errors using Migration Utility Interrupt Handler. 4.Mar 20, 2018 · The ability to predict accurately the levels of unsteady forcing on turbine blades is critical to avoid high-cycle fatigue failures. Further, a demonstrated ability to make accurate predictions ... Jul 7, 2021 · The influences of species, CO2 concentrations and planting year on AMF colonization were associated with their effects on both soil nutrient and AMF community, and the former may be more important ... Amazon Web Services 5G Network Evolution with AWS 2 communication service provider (CSP) in the telecom industry. Openness has been a long-standing requirement of CSPs and AWS Cloud provides exactly that – strong AMF Plus device and it will automatically receive the right firmware, licenses, and configuration from the Master. This enables plug-and-play replacement for end-of-life products. AMF Plus is a sophisticated suite of management tools that provide a simplified approach to network management. Migration and Integration Fund (AMIF), the undersigned organizations wish to reiterate and update their priorities in light of the new Pact on Migration and Asylum. The present statement builds upon previous collective recommendations and concerns relating to the AMIF proposal highlighted in February 2019 and November 2019.three-day weekend to allow for the migration and unforeseen challenges, the system and data migration was complete in just 14 hours. The go-live decision was made on day two. The system went live on schedule with a normal production workload. The phase two migration, planned for a normal two-day weekend, was successfully completed in under 24 ...• Venues to discuss migration data and disaggregation by migratory status • Capacity development 4.0 ( PARIS21) • Use of big data and geospatial information ( UN‐GGIM, UN GWG on Big Data for Official Statistics) • Mapping of global indicators by member states in their context. 7. Click Finish. 8. Save your work and click Restart Now to complete the installation if prompted. 9. Click New Server. 10. Enter vditest.jmhconnect.net then click Connect.of Migration and Border Studies), Vincent Chetail (Refugee Survey Quarterly), Howard Duncan (International Migration), Alan Gamlen (Migration Studies), Donald Kerwin (Journal on Migration and Human Security), Emmanuel Ma Mung and Véronique Petit (Revue Européenne des Migrations Internationales), AnnaThe proposal for a regulation establishing the Asylum and Migration Fund (AMF) is part of the European Commission’s proposal for the next Multi-annual Financial Framework (2021-2027). The overall MFF proposal foresees a significant increase in the amount of money awarded to migration andJan 14, 2020 · On the other hand, migration is the process of leaving one's own country or moving within a state to live elsewhere, regardless of the migrant's legal status, the nature of their journey ... Sep 9, 2018 · The proposal for a regulation establishing the Asylum and Migration Fund (AMF) is part of the European Commission’s proposal for the next Multi-annual Financial Framework (2021-2027). The overall MFF proposal foresees a significant increase in the amount of money awarded to migration and On the other hand, migration is the process of leaving one's own country or moving within a state to live elsewhere, regardless of the migrant's legal status, the nature of their journey ...1.Increased glycolysis is linked with increased cell migration and invasion in glioblastoma cells. 2.The glycolysis enzyme GPI/AMF may serve as a target for antimetabolic and anti-invasive therapy. 3.Despite reducing tumor invasion, GPI/AMF targeting may have unwanted growth stimulatory effects.Sustainable Development Goals (SDGs) include migration-related targets on labour standards, human trafficking, transfer costs of remittances, etc. Target 10.7 calls on countries to facilitate safe, orderly and regular migration and to implement well-managed migration policies. Keeping track of the implementation 5 Term Description ML Machine Learning MME Mobile Mobility Entity mMTC Mobile Machine Type Communications MO SMS Mobile-Originated Short MessageDefine and frame the use of AMF in non EU countries The AMF proposal enables third countries associated to the fund to be direct beneficiaries of Member States’ national programmes for the purpose of managing migration, and includes measures regarding readmission procedures, return and reintegration, as well as resettlement schemes. Jan 14, 2020 · On the other hand, migration is the process of leaving one's own country or moving within a state to live elsewhere, regardless of the migrant's legal status, the nature of their journey ... Ericsson CTO Erik Ekudden’s view on a robust 5G migration strategy . For many operators, the introduction of the 5G System (5GS) to provide wide-area services in existing Evolved Packet System (EPS) deployments is a necessary step toward creating a full-service, future-proof 5GS in the longer term.2 Each of these questions may have appeared futuristic not so long ago. But today, there is a rapidly growing consensus that artificial intelligence can revolutionise humanZusammenfassung. Ziel der Untersuchung ist es zum einen abzuschätzen, inwieweit das inländische Potenzial zur Rekrutierung von Arbeitskräften für die Altenpflege in Deutschland zur Deckung des prognostizierten Bedarfs im Jahr 2030 ausreicht. Zum anderen werden die Chancen und Hemmnisse der Rekrutierung ausländischer Pflegekräfte sowohl ...The momentum to improve international migration statistics has never been stronger. For many years, the General Assembly has called for accurate, timely and disaggregated statistics on international migration. The adoption of the 2030 Agenda for Sustainable Development and the New York Declaration for Refugees and Migrants have added further urgency to the need to strengthen national ...M. P. Todaro. The literature on international migration from developing countries has expanded considerably in recent years. Much of it tends to be empirical and policy-oriented with the majority ...Sustainable Development Goals (SDGs) include migration-related targets on labour standards, human trafficking, transfer costs of remittances, etc. Target 10.7 calls on countries to facilitate safe, orderly and regular migration and to implement well-managed migration policies. Keeping track of the implementation The Asylum, Migration and Integration Fund (AMIF) was set up for the period 2014-20, with a total of EUR 3.137 billion for the seven years. It will promote the efficient management of migration flows and the implementation, strengthening and development of a common Union approach to asylum and immigration. Zusammenfassung. Ziel der Untersuchung ist es zum einen abzuschätzen, inwieweit das inländische Potenzial zur Rekrutierung von Arbeitskräften für die Altenpflege in Deutschland zur Deckung des prognostizierten Bedarfs im Jahr 2030 ausreicht. Zum anderen werden die Chancen und Hemmnisse der Rekrutierung ausländischer Pflegekräfte sowohl ...Define and frame the use of AMF in non EU countries The AMF proposal enables third countries associated to the fund to be direct beneficiaries of Member States’ national programmes for the purpose of managing migration, and includes measures regarding readmission procedures, return and reintegration, as well as resettlement schemes. The proposal for a regulation establishing the Asylum and Migration Fund (AMF) is part of the European Commission’s proposal for the next Multi-annual Financial Framework (2021-2027). The overall MFF proposal foresees a significant increase in the amount of money awarded to migration andSollte die VDHI einen Interessenkonflikt nicht vermeiden können, werden die Kunden auf die Art des Konfliktes und seine Ursachen hingewiesen. Unvermeidbare Interessenkonflikte können sich daraus ergeben, dass Produkte der VDHI in die Investmentfonds erworben werden, für deren Verwaltung die VDHI eine Verwaltungsvergütung erhält.Aug 26, 2022 · Migration is understood as the temporary movement from the country of birth to the country of residence and immigration refers to a permanent movement. Reasons for migration are mostly due to work, family, or study. Refugees, however, are forced to leave their country due to e.g., political conflicts or disasters and are highly vulnerable. three-day weekend to allow for the migration and unforeseen challenges, the system and data migration was complete in just 14 hours. The go-live decision was made on day two. The system went live on schedule with a normal production workload. The phase two migration, planned for a normal two-day weekend, was successfully completed in under 24 ... The proposal for a regulation establishing the Asylum and Migration Fund (AMF) is part of the European Commission’s proposal for the next Multi-annual Financial Framework (2021-2027). The overall MFF proposal foresees a significant increase in the amount of money awarded to migration andMove the image to the Proxmox VE Server. Plug a USB Hard Drive into the server. From the Proxmox VE command line: mkdir /mnt/usb. mount /dev/sdc1 /mnt/usb/. ls /mnt/usb. You should see the contents of the USB drive. In my case, the vmdk file was located in /mnt/usb/windows-server/. of Migration and Border Studies), Vincent Chetail (Refugee Survey Quarterly), Howard Duncan (International Migration), Alan Gamlen (Migration Studies), Donald Kerwin (Journal on Migration and Human Security), Emmanuel Ma Mung and Véronique Petit (Revue Européenne des Migrations Internationales), Anna The Asylum, Migration and Integration Fund (AMIF) is set up for the period 2021-2027, with a total of EUR 9.88 billion.The Fund aims to further boost national capacities and improve procedures for migration management, as well as to enhance solidarity and responsibility sharing between Member States, in particular through emergency assistance and the relocation mechanism.These AMF effects improved leaf and root biomass by 43.87% and 59.71% and facilitated recovery of a conservative root economic strategy. It is speculated that AMF induces the resistance signal switch by regulating the negative feedback regulation mode of indole acetic acid upward transport and methyl jasmonate downward transmission in plants.AMF - Objectives Effective management of migration flows Common European Asylum System legal migration Integration and Return Solidarity and responsibility sharing Ensure efficient and uniform application of the Union acquis on asylum Set up and develop integration strategies at local/regional level (two way dynamic process, specific needs,Autocrine motility factor (AMF) is a tumor-secreted cytokine that acts as a motogen as well as a mitogen via a receptor-mediated signaling pathway(s). Expression of the AMF receptor (AMF-R) in normal cells is regulated by cell contact whereas in transformed cells AMF-R is constitutively expressed irrespective of cell density.International Migration and Development (HLD) in September 2006. Taken together, these initiatives signal both a growing consensus that interna-tional migration can have important impacts on development, and that it is an important opportunity to develop policy interventions that will help realize the full potential of international migration.The proposal for a regulation establishing the Asylum and Migration Fund (AMF) is part of the European Commission’s proposal for the next Multi-annual Financial Framework (2021-2027). The overall MFF proposal foresees a significant increase in the amount of money awarded to migration andWe demonstrated that AMF/PGI transactivates the MMP-3 gene promoter through AP-1. The transactivation and induction of cell migration effect of AMF/PGI directly correlates with its enzymatic activity. Various analyses showed that AMF/PGI stimulated the Src-RhoA-PI3-kinase signaling pathway, and these three signaling molecules could form a complex.The Asylum, Migration and Integration Fund (AMIF) was set up for the period 2014-20, with a total of EUR 3.137 billion for the seven years. It will promote the efficient management of migration flows and the implementation, strengthening and development of a common Union approach to asylum and immigration.AMF - Objectives Effective management of migration flows Common European Asylum System legal migration Integration and Return Solidarity and responsibility sharing Ensure efficient and uniform application of the Union acquis on asylum Set up and develop integration strategies at local/regional level (two way dynamic process, specific needs,Define and frame the use of AMF in non EU countries The AMF proposal enables third countries associated to the fund to be direct beneficiaries of Member States’ national programmes for the purpose of managing migration, and includes measures regarding readmission procedures, return and reintegration, as well as resettlement schemes.Mar 5, 2018 · Migration Utility product. The source code remains in the original library 4) IBM Migration Utility for z/OS creates IBM standard COBOL syntax from EasyTrieve Plus language statements, without having to have the EasyTrieve product installed. The IBM Migration Utility runs in place of the EasyTrieve Plus interpreter. Source code, written in Importance of Migration Statistics The importance of migration data to decision makers, planners, international organizations and other users is to identify its size, levels and trends in Jordan. The aim is to contribute to making the right decisions and necessary measures to tackle and organize this phenomenon. The country can also directWe demonstrated that AMF/PGI transactivates the MMP-3 gene promoter through AP-1. The transactivation and induction of cell migration effect of AMF/PGI directly correlates with its enzymatic activity. Various analyses showed that AMF/PGI stimulated the Src-RhoA-PI3-kinase signaling pathway, and these three signaling molecules could form a complex.Mar 5, 2018 · Migration Utility product. The source code remains in the original library 4) IBM Migration Utility for z/OS creates IBM standard COBOL syntax from EasyTrieve Plus language statements, without having to have the EasyTrieve product installed. The IBM Migration Utility runs in place of the EasyTrieve Plus interpreter. Source code, written in Natural and uninterrupted water courses are important for biodiversity and fish population stability. Nowadays, many streams and rivers are obstructed by artificial migration barriers, often preventing the migration of fish. On the other hand, distribution of pathogens by migrating fishes is still a point of concern. Pathogen transport and transmission is a driving force in the dynamics of ...Bat migrations have been studied for a long time, but large areas remain poorly explored in this regard. This note reports a record migration distance of the Nathusius’ pipistrelle – 2486 km from Russia to the French Alps. This distance exceeds the previous record flight from Latvia to Spain by 260 km. Hibernating colonies of Nathusius’ pipistrelle are known in the Caucasus. However, our ... county and inter-state migration of pre-war birth cohorts in the U.S. Their analysis shows that married individuals have lower rates of migration than do singles, and that the rates of migration decrease significantly as family size increases. The authors conclude that two factors are responsible for this reduction.AMF produced by HCC induce migration of MSCs from different sources AMF enhances BM-MSC migration by stimulating A 55 KDa soluble AMF form was detected in the conditioned endothelial cell adhesion and modulating relevant genes medium of cell culture monolayers (CCM) and SC tumors (TCM) Potent and specific MSC migration toward HCC is critical ...To obtain further evidence for GPI/AMF acting as autocrine stimulator of glioblastoma cell migration as well as to evaluate its role in vivo, we silenced GPI/AMF expression. Initially, GS-11, GS-12, and G55 cells were transduced with 6 different shRNAs targeting GPI/AMF (shAMF) or with nonsilencing control shRNA (shControl).States on asylum and migration, in particular by supporting funds to pool best practice on asylum. This can be done in part by setting up networks and exchanging information on legal migration and the integration of third-country nationals. 1.10 The EESC welcomes the importance given to flexibility in both funds, as this entails acknowledging To ensure consistency, AMF and other internal affairs funds should not be used to establish new detention infrastructures or to detain children or their families. The future of the Asylum, Migration and Integration Fund Our call for more humane, transparent and effective resources for asylum and migration in the Union November 2019migration is from Ghoramara, so much so that even some available land lies fallow and neglected, which makes it more vulnerable to saline water inundation because no one repairs the embankments ...Mar 20, 2018 · The ability to predict accurately the levels of unsteady forcing on turbine blades is critical to avoid high-cycle fatigue failures. Further, a demonstrated ability to make accurate predictions ... The momentum to improve international migration statistics has never been stronger. For many years, the General Assembly has called for accurate, timely and disaggregated statistics on international migration. The adoption of the 2030 Agenda for Sustainable Development and the New York Declaration for Refugees and Migrants have added further urgency to the need to strengthen national ...Migration policy framework for Africa and plan of action (2018 – 2030) Preface. Due to a multiplicity of factors that include poor socio-economic . conditions, political instability, conflict and civil strife, migration has been on the rise on the African Continent, and for some communities migration has become a survival strategy. InJul 22, 2010 · DOC-2012-02 Corporate governance and executive compensation in companies referring to the AFEP-MEDEF code - Consolidated presentation of the recommendations contained in the AMF annual reports; DOC-2015-05 Major Asset Disposals and Acquisitions; DOC-2011-17 AMF 2011 annual report on corporate governance and executive compensation that the AMF fully addresses key issues and challenges identified on the ground. Therefore, we would like to urge the Council, the European Parliament and the European Commission to ensure that the partnership principle with international and civil society organisations is made mandatory for the Asylum and Migration Fund.pET5a-AMF transformed E. coli JM 109 cells were selected by ampicillin and at least 200 clones were analyzed for AMF expression by Western blotting using anti-AMF antibodies. The rhAMF appears as a 55 kDa protein under non-reducing conditions ( Fig. 1A ), in accordance with the previously reported molecular sizing of AMF (55 kDa [25] ), NLK (56 ...Mar 5, 2018 · Catalog; For You; The Guardian Australia. Housing report says migration may need to be cut to preserve quality of life 2018-03-05 - Gareth Hutchens . One of Australia’s most respected thinktanks has weighed into the population growth debate, saying the federal government needs to develop an explicit population policy that defines the “appropriat­e” level of migration, and it may need to ... Jul 27, 2017 · 6. Diet. There’s a laundry list of foods known to trigger a migraine attack, the most common ones being foods that contain histamine and MSG, chocolate, cheese and other dairy products, artificial sweeteners (e.g. aspartame), caffeine, cured meats, and anything with a strong smell. • Venues to discuss migration data and disaggregation by migratory status • Capacity development 4.0 ( PARIS21) • Use of big data and geospatial information ( UN‐GGIM, UN GWG on Big Data for Official Statistics) • Mapping of global indicators by member states in their context.Autocrine motility factor (AMF) is a tumor-secreted cytokine that acts as a motogen as well as a mitogen via a receptor-mediated signaling pathway(s). Expression of the AMF receptor (AMF-R) in normal cells is regulated by cell contact whereas in transformed cells AMF-R is constitutively expressed irrespective of cell density. DOC-2012-02 Corporate governance and executive compensation in companies referring to the AFEP-MEDEF code - Consolidated presentation of the recommendations contained in the AMF annual reports; DOC-2015-05 Major Asset Disposals and Acquisitions; DOC-2011-17 AMF 2011 annual report on corporate governance and executive compensation

Mar 5, 2018 · It calls for the disaggregation of migration data by sex and age, and the inclusion of information on regular and irregular flows, the economic impacts of migration and refugee movements, human trafficking, the needs of refugees, migrants and host communities and other issues. . H5322 031

20180305_publikation_amf_migration_vdhi.pdf

1 INTRODUCTION. The COVID-19 pandemic has profoundly altered people's daily lives. Various measures implemented by governments to limit the spread of the virus ranged from social distancing (e.g., closure of restaurants, recreational facilities, childcare and educational facilities) to restrictions of international and national travel and lockdowns (Alipour et al., 2020; Karako et al., 2020 ...This paper demonstrates the application of the AMF model to simulate delamination migration in composite laminates by refining the fidelity of FE model locally in order to predict damage progression. The numerical results obtained from the AMF model are validated with experiments and full 3D models.7. Click Finish. 8. Save your work and click Restart Now to complete the installation if prompted. 9. Click New Server. 10. Enter vditest.jmhconnect.net then click Connect.Container 1 had no AMF inoculation (Ctrl/Ctrl and Ctrl/pathogen treatments in Table 1), and containers 2, 3 and 4 had 101-14, 5C and Schwarzmann AMF communities (AMF/Ctrl and AMF/pathogen treatments), respectively. The pumice in each container was inoculated with approximately 10,000 spores (5 spores/g) at the corresponding AMF community ...Mar 28, 2014 · We present data on bilateral flows between 196 countries from 1990 through 2010 that provide a comprehensive view of international migration flows. Our data suggest a stable intensity of global 5-year migration flows at ~0.6% of world population since 1995. In addition, the results aid the interpretation of trends and patterns of migration ... • Venues to discuss migration data and disaggregation by migratory status • Capacity development 4.0 ( PARIS21) • Use of big data and geospatial information ( UN‐GGIM, UN GWG on Big Data for Official Statistics) • Mapping of global indicators by member states in their context.This paper surveys our understanding of how migration affects growth and inequality through the impact on migrants themselves as well as on the destination and origin countries. JEL Classification Numbers: F22, O15, F63, J61. Keywords: International Migration, Inequality, Economic growth. Authors’ E-Mail Addresses:Define and frame the use of AMF in non EU countries The AMF proposal enables third countries associated to the fund to be direct beneficiaries of Member States’ national programmes for the purpose of managing migration, and includes measures regarding readmission procedures, return and reintegration, as well as resettlement schemes. Bat migrations have been studied for a long time, but large areas remain poorly explored in this regard. This note reports a record migration distance of the Nathusius’ pipistrelle – 2486 km from Russia to the French Alps. This distance exceeds the previous record flight from Latvia to Spain by 260 km. Hibernating colonies of Nathusius’ pipistrelle are known in the Caucasus. However, our ... three-day weekend to allow for the migration and unforeseen challenges, the system and data migration was complete in just 14 hours. The go-live decision was made on day two. The system went live on schedule with a normal production workload. The phase two migration, planned for a normal two-day weekend, was successfully completed in under 24 ...Jul 24, 2018 · To obtain further evidence for GPI/AMF acting as autocrine stimulator of glioblastoma cell migration as well as to evaluate its role in vivo, we silenced GPI/AMF expression. Initially, GS-11, GS-12, and G55 cells were transduced with 6 different shRNAs targeting GPI/AMF (shAMF) or with nonsilencing control shRNA (shControl). Nov 12, 2018 · 1.Increased glycolysis is linked with increased cell migration and invasion in glioblastoma cells. 2.The glycolysis enzyme GPI/AMF may serve as a target for antimetabolic and anti-invasive therapy. 3.Despite reducing tumor invasion, GPI/AMF targeting may have unwanted growth stimulatory effects. In order to To examine whether AMF produced by HCC might affect elucidate the molecular mechanisms behind the increased MSC migration, TCM obtained from HuH7 or HC-PT-5 tumors chemotactic and adhesion properties induced by rAMF-pretreat- PLOS ONE | www.plosone.org 4 April 2014 | Volume 9 | Issue 4 | e95171 AMF and Mesenchymal Stem Cell ...The influences of species, CO2 concentrations and planting year on AMF colonization were associated with their effects on both soil nutrient and AMF community, and the former may be more important ...2. LEGAL BASIS, SUBSIDIARITY AND PROPORTIONALITY • Legal basis Article 3(2) of the Treaty on European Union provides that ‘the Union shall offer its citizens an area of freedom, security and justice without internal frontiers, in which the free movement of persons is ensured in conjunction with appropriate measures with respect to external border controls, asylum, immigration and the ... Jul 7, 2021 · The influences of species, CO2 concentrations and planting year on AMF colonization were associated with their effects on both soil nutrient and AMF community, and the former may be more important ... diminished considerably. Institutional barriers to migration (for example, land tenure security and access to credit) are also changing, albeit more slowly. Taken together, these trends provide good reason to regularly revisit migration trends and associated labor market developments as new data become available..

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